Barcelona snapshots

Prof. Andreas Meyer-Lindenberg

Andreas Meyer-Lindenberg psychiatrist Controversies Psiquiatry Barcelona
Universität Heidelberg, Germany
Talk Neural mechanisms and neuroimaging in precision psychiatry
Date Friday, April 21st, 2023
Time 10:00 - 10:45
Round Table 2 Precision diagnosis in psychiatry: are we going to succeed in changing the model?


Prof. Meyer-Lindenberg is Director of the Central Institute of Mental Health, as well as the Medical Director of the Department of Psychiatry and Psychotherapy at the Institute, based in Mannheim, Germany and Professor and Chairman of Psychiatry and Psychotherapy at the University of Heidelberg in Heidelberg, Germany. He is board certified in psychiatry, psychotherapy, and neurology. Before coming to Mannheim in 2007, he spent ten years as a scientist at the National Institutes of Mental Health, Bethesda, USA.

Prof. Meyer-Lindenberg is the author of more than 480 peer-reviewed articles and book chapters. He is continuously named as one of the most highly cited scientists in the world. He is Editor-in-Chief of the new Journal of the ECNP Neuroscience Applied, associate editor of Science Advances and on the editorial board of a number of other journals.

His research interests focus on the development of novel treatments for severe psychiatric disorders, especially schizophrenia, through an application of multimodal neuroimaging, genetics and enviromics to characterize brain circuits underlying the risk for mental illness and cognitive dysfunction.

In recognition of his research, Prof. Meyer-Lindenberg has received awards throughout his career, including the Joel Elkes International Award for Clinical Research from the American College of Neuropsychopharmacology (2006), the A.E. Bennett Award of the Society for Biological Psychiatry (2007), Kurt Schneider Scientific Award (2010), the Hans-Jörg Weitbrecht-Preis für Klinische Neurowissenschaften (2011), the ECNP Neuropsychopharmacology Award, 2012, the Prix ROGER DE SPOELBERCH (2014), and the 2016 CINP Lilly Neuroscience Clinical Research Award (2016).


The complexity of mental disorders poses a challenge for precision psychiatry. There is a growing consensus that categorical diagnoses, while reliable, have insufficient validity with regard to the underlying pathophysiology to support personalized treatments. Thus, precision psychiatry requires a pathway from an in-depth pheno- and genotype characterization to stratification and assignment of interventions. In this talk, I will argue that (1) neuroimaging supports this concepts by identifying systems-level variation dimensionally linked to treatment-relevant factors across diagnoses, (2) that neuroimaging can be integrated with other information sources to identify individual risk and resilience profiles that can guide therapy and (3) that recent advanced in machine learning, especially in deep neural networks, will be crucial in achieving this goal. I will also highlight the need to pay closer attention to the temporal characteristics of brain disorders, both across the life span and within an individual episode, to overcome the problem of non-ergodicity of mental processes that currently limits precision psychiatry.


[Full paper] 1. Schwarz K, Moessnang C, ...., Meyer-Lindenberg A. (2020). Transdiagnostic Prediction of Affective, Cognitive, and Social Function Through Brain Reward Anticipation in Schizophrenia, Bipolar Disorder, Major Depression, and Autism Spectrum Diagnoses. Schizophrenia bulletin 46:592-602

2. Meyer-Lindenberg A. (2010). From maps to mechanisms through neuroimaging of schizophrenia. Nature 468:194-202

3. Tost H, Reichert M, ...., Meyer-Lindenberg A. (2019). Neural correlates of individual differences in affective benefit of real-life urban green space exposure. Nature neuroscience 22:1389-1393